Welcome to Yue Lab

About the PI: Dr. Yue is the founding director of the Center for Cancer Genomics at the Robert H. Lurie Comprehensive Cancer Center and the Duane and Susan Burnham Professor of Molecular Medicine. He is a tenured Associate Professor in the Department of Biochemistry and Molecular Genetics. Previously, he was an associate professor at the Pennsylvania State University and director of Bioinformatics Division at the Penn State Institute for Personalized Medicine.

        The main research area for Dr. Yue's group is epigenomics and 3D genome organization in the context of human diseases. He completed his Ph.D. in Computure Science from University of South Carolina, and recieved his postdoctoral training from Dr. Bing Ren at UCSD. Dr. Yue has been an active member of several large NIH funded consortia, including the ENCODE, Roadmap/Epigenomics, and 4D Nucleome projects. During the period, he lead the integrative analysis effort for the mouse ENCODE consortium (Yue et al., Nature 2014). Currently, he is serving as co-chair for the Integrative Analysis Workgroup in the 4D Nucleome Project.

About the lab: Our lab is located in the new 12-story Simpson Querrey Biomedical Research Center at Northwestern University Feinberg School of Medicine. Right now, we have one Principal Investigator, one assistant professor, four postdoc fellows, and 10 graduate students. Half of the people in the lab come from genetics background and the other half were trained in bioinformatics/computational biology.

Recent News:

1. New lab preprint: A supervised learning framework for chromatin loop detection in genome-wide contact maps. [Manuscript], [Download].
2. Our lab moved from Penn State to Northwestern University in July, 2019. [News release]
3. Yali and Bo's paper studying the function of Ikaros on enhancer activities is published in Leukemia. Great collaboration with Dr. Dovat. [Paper]
4. Our manuscript describing the 3D genome browser is published in Genome Biology. [Paper]
5. Our collaborative work on using Hi-C, optical mapping and WGS to detect SVs in cancer genomes and their impact on 3D genome structure is published in Nature Genetics. [Paper]