Welcome to Yue Lab at Penn State

About the PI: Dr. Yue is a tenure-track assistant professor in the Dept. of Biochemistry and Molecular Biology at Penn State School of Medicine. He serves as the director of Bioinformatics division for the Penn State Institute for Personalized Medicine (IPM). He has been an active member of several NIH funded consortia, including the ENCODE, Roadmap/Epigenomics, and 4D Nucleome projects. Currently, he is co-chairing the 4D Nucleome integrative analysis workgroup.

        The main research area for Dr. Yue's group is cancer epigenomics and 3D genome organization. Before joining Penn State, Dr. Yue received his postdoctoral training in Dr. Bing Ren's laboratory at UCSD School of Medicine. He is a graduate advisor in the BMS program and the Genomics and Bioinformatics Program.

About the lab: Our lab was established in Oct. 2013 with both web lab and dry lab components. Right now, we have one Principal Investigator, one assistant professor, two postdoc fellows, 10 graduate students and two visiting scholars. Half of the people in the lab come from genetics background and the other half works on computational biology.

Recent News:

1. Our manuscript describing the 3D genome browser has been published by Genome Biology (link).
2. Our collaborative work on using Hi-C, optical mapping and WGS to detect SVs in cancer genomes and their impact on 3D genome structure has been published by Nature Genetics. Here is the paper.
3. We received a R01 grant from NHGRI/NIH!
4. We received a Maximizing Investigators' Research Award (MIRA, R35) from NIGMS/NIH!
5. Yan and Lin's paper on using deep-learning to enhance the Hi-C data resolution (HiCPlus) has been published in Nature Communications.
6. Tao's paper on Hi-C data reproducibility (HiCRep) has been published in Genome Research.