Welcome to Yue Lab
About the PI: Dr. Feng Yue is Associate Director for AI and Data Science at the Robert H. Lurie Comprehensive Cancer Center of Northwestern University and the founding director of the Center for Cancer Genomics. He also directs the Center for Advanced Molecular Analysis at the Northwestern Institute for Artificial Intelligence in Medicine, and is the Duane and Susan Burnham Professor of Molecular Medicine, Professor of Biochemistry and Molecular Genetics, and Professor of Pathology. He serves as a Deputy Editor at Science Advances, overseeing work in genomics, computational biology, and AI/machine learning.
The Yue Lab develops and applies advanced genomic technologies and computational methods to understand how the genome is organized and regulated in normal development and cancer. The laboratory integrates 3D genomics, epigenomics, spatial and single-cell technologies, machine learning, and CRISPR-based genome engineering to study gene regulation, structural variation, and the functional consequences of genetic and epigenetic alterations. A major focus of the laboratory is cancer genomics and epigenomics. The group has demonstrated how alterations in epigenetic regulation, 3D genome organization, and structural variation contribute to gene dysregulation and tumor biology across multiple cancer types, including leukemia, bladder cancer, brain tumors, and colorectal cancer.
Dr. Yue received his Ph.D. in Computer Science from the University of South Carolina and completed his postdoctoral training with Dr. Bing Ren at the University of California, San Diego. He has been an active member of several major NIH-funded genomics consortia, including ENCODE, Roadmap Epigenomics, 4D Nucleome, and the Impact of Genomic Variation on Function Consortium (IGVF). He led integrative analysis efforts for the mouse ENCODE Consortium, currently serves as co-chair of the Integrative Analysis Working Group of the 4D Nucleome Project, and co-chairs the Steering Committee of the IGVF Consortium.
Training record: The Yue Lab has graduated ten Ph.D. students, each with at least one first-author publication from their doctoral research, including papers in Science Advances, Nature Communications, and Nature Genetics. In addition, six former postdoctoral fellows from the lab have gone on to establish independent research programs as principal investigators. Lab alumni have also joined leading biotechnology and pharmaceutical companies upon graduation, such as Illumina and Regeneron.
Recent News:| 2026.09.01 | Our Spatial-ATAC-Hi-C study was published in Nature Methods. | |
| 2026.02.17 | Northwestern launched the new Computational Biology and Bioinformatics Ph.D. Track, directed by Dr. Yue | |
| 2025.06.09 | Dr. Yue has been inducted into the 2025 class of the American Institute for Medical and Biological Engineering (AIMBE) College of Fellows. [News Release] | |
| 2025.04.28 | Dr. Yue received the Mark Brothers Award. [News] | |
| 2024.09.10. | Dr. Yue won the Dean's Teaching Award for his contribution to the DGP curriculum and Bioinformatics edution. | |