Welcome to Yue Lab

About the PI: Dr. Yue is the founding director of the Center for Cancer Genomics at the Robert H. Lurie Comprehensive Cancer Center of Northwestern University, director of the Center for Advanced Molecular Analysis at Northwestern Institute for Augmented Intelligence in Medicine, and the Duane and Susan Burnham Professor of Molecular Medicine. He is a tenured Associate Professor in the Department of Biochemistry and Molecular Genetics, and the Department of Pathology.

        The main research area for Dr. Yue's group is epigenomics and 3D genome organization in the context of human diseases. He completed his Ph.D. in Computure Science from University of South Carolina, and recieved his postdoctoral training from Dr. Bing Ren at UCSD. Dr. Yue has been an active member of several large NIH funded consortia, including the ENCODE, Roadmap/Epigenomics, and 4D Nucleome projects. During the period, he lead the integrative analysis effort for the mouse ENCODE consortium (Yue et al., Nature 2014). Currently, he is serving as co-chair for the Integrative Analysis Workgroup in the 4D Nucleome Project. He also Co-chairs the Steering Committee of the NIH Impact of Genomic Variation on Function Consortium (IGVF).

        Our group also has a strong interested in cancer genomics and has demonstrated how epigenome and 3D genome structure are altered and led to gene dysregulation in different types of tumor, such as leukemia, bladder cancer, and brain tumor (Ding et al. Leukemia 2019, Iyyanki et al. Genome Biol. 2021, Wang et al. Science Adv. 2021). Click here to see Dr. Yue's complete CV.

About the lab: Our lab is well-versed in both computational biology and functional genomics. It is located in the new 12-story Simpson Querrey Biomedical Research Center at Northwestern University Feinberg School of Medicine. Right now, we have one Principal Investigator, one assistant professor, four postdoc fellows, and 10 graduate students. Half of the people in the lab come from genetics background and the other half were trained in bioinformatics/computational biology.

Training record: Our lab has graduated seven Ph.D. students and each of them has at least one first-author publication upon their graduation in journals such as Genome Research, Nature Communications, or Nature Genetics. Two of them continued their training in Md/PhD program; the rest of them either joined pharmaceutical companies or pursue postdocs.

Recent News:

1. We will be co-leading the IGVF consoritum Data Coordination and Administrative Center with Dr. Ting Wang from WashU. The IGVF consotium consists of 30 US insitutes and NHGRI/NIH will provide approximately $185 million over the next five years.More about IGVF Consortium.
2. Our work on method to predict enhancer hijacking in cancer genome came out in Nature Methods.
3. News coverage for our recent work on 3D genome structure in bladder cancer and pediatric brain tumor. Feinberg News Center.
4. Our work on zebrafish epigneome annotation, 3D genome organization, sex chromosome assembly is published in Nature.
5. Fan defended his PhD thesis on 05/15/2021. Congratuations, Dr. Fan Song!
6. Dr. Yue joined the editorial board of Genome Research and Science Advances.